Name：Thiamine
hydrochloride
Synonyms：Vitamin B1 hydrochloride; Aneurine hydrochloride
Molecular Structure：
Molecular Formula：C12H17ClN4OS.HCl
Molecular Weight：337.27
CAS Registry Number：67-03-8
EINECS：200-641-8
Melting point：246-254 ºC
Water solubility：1 g/mL
Functions：
Thiamin may enhance circulation, helps with blood formation and the
metabolism of carbohydrates. It is also required for the health of the
nervous system and is used in the biosynthesis of a number of cell
constituents, including the neurotransmitter acetylcholine and gamma-aminobutyric
acid (GABA). It is used in the manufacture of hydrochloric acid, and
therefore plays a part in digestion.
It is also great for the brain and may help with depression and assist
with memory and learning. In children it is required for growth and has
shown some indication to assist in arthritis, cataracts as well as
infertility.
Deficiency of vitamin B1
A deficiency will result in beriberi, and minor deficiencies may be
indicated with extreme fatigue, irritability, constipation, edema and an
enlarged liver. Forgetfulness, gastrointestinal disturbances, heart
changes, irritability, labored breathing and loss of appetite may also
be experienced.
With too little thiamin around a person may also experience nervousness,
numbness of the hands and feet, pain and sensitivity, poor coordination,
tingling sensations, weak and sore muscles, general weakness and severe
weight loss.
Dosage
The dosage underneath is the Recommended Dietary Allowance (RDA), but be
aware that this dosage is the minimum that you require per day, to ward
off serious deficiency of this particular nutrient. In the therapeutic
use of this nutrient, the dosage is usually increased considerably, but
the toxicity level must be kept in mind.
Male 1.4 mg per day and female 1.0 mg per day, although 50 mg is usually
used in supplementation.
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